Muscadine Grape Seed Extract

This physician-formulated polyphenol-rich formula delivers concentrated Muscadine Grape (Vitis rotundifolia) seed extract—a uniquely potent grape variety native to the southeastern United States that contains higher polyphenol concentrations than European grape varieties, including an extra chromosome that confers exceptional antioxidant capacity. Targeting cardiovascular health, skin vitality, and cellular longevity pathways, this formula provides elite polyphenol protection for adults seeking superior antioxidant defence.

•        Delivers exceptional OPC and resveratrol polyphenol antioxidant protection

•        Supports cardiovascular health, blood pressure, and endothelial function

•        Promotes skin elasticity, collagen support, and healthy ageing

•        Provides anti-inflammatory support for joints and tissues

•        Supports healthy blood sugar and metabolic balance

•        Promotes cellular longevity and protection against oxidative ageing

Muscadine grapes (Vitis rotundifolia) are native to the American South and are genetically distinct from European and other grape species, containing 40 chromosomes compared to the standard 38. This unique genetics results in significantly higher concentrations of ellagic acid, quercetin, myricetin, kaempferol, and stilbene polyphenols—particularly resveratrol and pterostilbene—than comparable grape seed extracts. Muscadine seeds are also particularly rich in oligomeric proanthocyanidins (OPCs) that support vascular health, collagen cross-linking, and antioxidant protection.

Muscadine Grape Seed Extract (Vitis rotundifolia, std. OPCs)

Standardised extract from Muscadine grape seeds, concentrated for oligomeric proanthocyanidins (OPCs), ellagic acid, quercetin, and stilbene polyphenols. Muscadine OPCs support vascular health, collagen structure, skin elasticity, and provide superior free radical scavenging compared to standard grape seed extracts.

Resveratrol (trans-Resveratrol)

A bioactive stilbene found in high concentrations in Muscadine grapes. Resveratrol activates sirtuin longevity pathways, supports cardiovascular endothelial function, modulates inflammatory signalling, and provides potent antioxidant protection. Synergistically amplified by Muscadine OPCs.

Pterostilbene

A dimethylated analogue of resveratrol found naturally in Muscadine grapes, with superior bioavailability and longer half-life. Pterostilbene supports cognitive health, blood sugar balance, cardiovascular wellness, and cellular longevity pathways.

Vitamin C (Ascorbic Acid)

An essential partner to OPC polyphenols—Vitamin C regenerates oxidised OPCs back to their active antioxidant form, extending and amplifying the antioxidant activity of the Muscadine polyphenol complex. Also supports collagen biosynthesis and skin health.

Quercetin

A synergistic flavonoid that complements Muscadine OPCs in modulating inflammatory enzyme pathways, supporting immune function, and providing cardiovascular antioxidant protection. Naturally present in Muscadine grapes and enhanced by standardised addition.

Support Area	Key Ingredient Action
OPC Antioxidant Defense	Muscadine OPCs provide elite free radical scavenging and vascular protection
Cardiovascular Support	Resveratrol and OPCs support endothelial function and healthy blood pressure
Skin & Collagen Health	OPCs support collagen cross-linking and skin elasticity
Cellular Longevity	Resveratrol and pterostilbene activate sirtuin longevity signalling
Metabolic Balance	Pterostilbene supports healthy blood sugar and insulin sensitivity

 

Polyphenol antioxidants, particularly OPCs and stilbenes from grape sources, represent some of the most extensively studied phytonutrients for cardiovascular health, skin ageing, and cellular longevity. Muscadine Grape Seed Extract offers a uniquely potent, native American polyphenol source with a richer bioactive profile than standard grape seed extracts—providing superior antioxidant and cardiovascular support for health-conscious adults.

•        Adults seeking elite cardiovascular antioxidant and vascular support

•        Individuals supporting healthy skin, collagen, and anti-ageing wellness

•        Those seeking polyphenol-based cellular longevity and metabolic support

•        Adults with high cardiovascular or oxidative stress risk factors

•        Individuals interested in unique, high-potency botanical polyphenol supplementation

•        Muscadine grape polyphenols and cardiovascular health — PubMed

•        Oligomeric proanthocyanidins (OPCs) and vascular function — PubMed

•        Pterostilbene bioavailability and metabolic support — PubMed

•        Resveratrol and sirtuin longevity pathways — PubMed